Take control of any hereditary genetic risk for cancer or heart disease with genetic testing for these conditions
Genetic testing, also known as DNA testing, can help you or family members identify whether you are at risk of developing common hereditary cancers or heart conditions.
Understanding your genetic risk affords you the opportunity to prevent disease or detect it at an earlier treatable stage.
This is not to be confused with ancestry DNA which helps to identify your origins.
The genetic testing we offer helps estimate your chance of developing cancer or cardiac problems in your lifetime and so allows you to take pro-active steps.
We offer a variety of packages that cover a wide range of genetic testing:
- BRCA1/BRCA2: detects cancer markers that significantly increase your risk of breast and ovarian cancer.
- Color 30 Gene Panel: analyses up to 30 genes associated with the most common hereditary cancers including breast, colorectal,
- melanoma, endometrial, prostrate, ovarian, stomach and uterine.
- 77 Cardiac Genes: covers heart disorders such as arrhythmia, cardiomyopathy, arteriopathy, blood pressure.
It’s also possible to do combined genetic testing for both cancer risk and heart disease with:
- Extended 30 Gene panel: combined screening including Color 30 Gene panel, BRCA 1/BRCA2 and cardiac profile.
Genetic cancer screening: BRCA and Color 30 Gene Panel
“Both men and women have a one in two risk of being diagnosed with a form of cancer in our lifetime.” Cancer Research UK
Proactive genetic testing enables you to learn about how your genes could potentially impact your health. It allows you and your healthcare provider to create a personalised health plan designed to prevent, detect and treat cancers early.
Today in the UK, women tend to be offered genetic testing for the corrupted gene if cancer runs in the family. By understanding their risk factor, women can be monitored more closely for cancer and if necessary, have preventative surgery.
It can also have a wider reaching impact and may be important information to share with your relatives. For example, if a man or woman carries a mutation in BRCA1, each of their parents (mother and father), siblings (brothers and sisters) and children (sons and daughters) have a 50% chance of carrying the same mutation.
BRCA gene testing
The name “BRCA” is an abbreviation for “BReast CAncer gene.” BRCA1 and BRCA2 are two different genes that have been found to impact a person’s chance of developing breast cancer.
A small percentage of people (about 1 in 400) carry mutated BRCA1 or BRCA2 genes. A BRCA mutation occurs when the DNA that makes up the gene becomes damaged in some way.
When a BRCA gene is mutated, it may no longer be effective at repairing broken DNA and helping to prevent breast cancer. Due to this , people with a BRCA gene mutation are more likely to develop breast cancer, and more likely to develop cancer at a younger age.
The carrier of the mutated gene can also pass a gene mutation down to his or her offspring and for some people, though, the chances of having a BRCA gene mutation are much higher. Genes are inherited, which is why knowing your family history is important when determining breast cancer risks.
With early detection, the vast majority of breast cancer cases can be successfully treated and that’s true even for people who have a BRCA1 or BRCA2 mutation.
Who should get BRCA testing?
In the UK around 1 in every 300-400 people carries a harmful BRCA mutation so everyone should do this test for peace of mind, although a person could be considered at high risk for BRCA mutations if they have a family history of:
- Breast cancer diagnosed before age 50.
- Male breast cancer at any age.
- Multiple relatives on the same side of the family with breast cancer.
- Multiple breast cancers in the same woman.
- Both breast and ovarian cancer in the same woman.
- Ashkenazi Jewish heritage.
Those with BRCA1 mutations are at significantly greater risk of developing certain cancers in their lifetime:
- Chances of getting ovarian cancer range between 10% and 60%, compared to a 2% risk for those without the mutation.
- Women have between a 45% and 90% risk of getting breast cancer, compared to 12.5% for those without the mutation.
Whether you are considered at high risk for BRCA mutations or not, this genetic test might change your life.
Color 30 Gene Panel Test: Hereditary Cancer Test
Understanding your genome structure provides many added benefits even if you don’t think there is a hereditary link. The tests we provide offer you the opportunity to get a comprehensive view of your health risks and work with our consultants to build a proactive health plan for your future.
Our tests provide:
- Clear results about the presence or absence of any mutations that increase your risk for developing cancer
- Detailed information on how your mutation status might effect relatives
- Personalised reports tailored to your personal health and family cancer history
- Support before, during and after you get your results.
Color 30 Gene Panel Cancer Test analyses 30 genes for mutations that could increase your risk for hereditary breast, colorectal, melanoma, ovarian, pancreatic, prostate*, stomach, and uterine cancers.
Genetic testing for cancer predisposition gives you personalised screening and prevention treatment
10-15% of most cancers are due to inherited genetics mutations.
Using just a sample of your saliva, we can now analyse for certain gene mutations that attribute to many common cancers.
Knowing you have a mutation that increases your risk allows you and your healthcare provider to create a personalised plan designed to prevent or detect cancer like breast, ovarian, colorectal, pancreatic, earlier or more treatable stage.
Prevention can be life-changing for you and your family!
Knowing you have a genetic mutation may be a piece of important information to share with your relatives. For example, if a man carries a mutation in BRCA1, each of his children has a 50% chance of carrying the same mutation.
“Genomics has the potential to transform the delivery of care for patients which is why the NHS has prioritised it in its Long Term Plan”
Prof Dame Sue Hill, Chief Scientific Officer of NHS England
Genome Testing & Heart Disease Prevention
Heart disease in many cases is caused by a combination of lifestyle choices – being overweight, having an unhealthy diet, smoking and drinking all increase your risks of suffering from this disease. However, studies show that for one in 200 people it can have a genetic basis.
As research and technology advances we are beginning to identify more genetic mutations that cause these heart conditions. Knowing if you are at risk allows you take early action on lifestyle change and can help you reduce your risk of developing this disease.
What is Inherited Heart Disease?
Inherited heart disease incorporates a range of conditions affecting the heart and circulatory system and can affect people of any age – it can be life-threatening. As there are many different types of inherited heart conditions, diagnosing the exact disease and gene mutation is key to providing effective treatment. The cardiac test covers 77 genes that are associated with an increased risk of the following types of heart disorders:
- Genetic forms of high blood pressure and high cholesterol
Genetic testing in this area provides you with the opportunity to determine if you have an increased risk of developing any of these conditions.
The information gathered from your results can then be used in combination with family and personal health history to create a personalised health plan.
How Does DNA Testing Work
The process for gathering a sample for your test is quick, simple and painless – all we need is a saliva sample. Below are step-by-step instructions for completing your test.
Request your kit
Contact our team and request a BRCA1 and BRCA2 test, 30 Gene Panel or Genetic Cardiac saliva test kit. We can then post it to you or you can pick one up from the Centre at your convenience.
Provide a saliva sample
Use the tube in your kit to provide a saliva sample and complete the request and consent form. You can do
this at home or at the Centre.
Return the kit
You can either return the kit to the Centre where we will be happy to post this for you, or you can post the sample pack
free of charge at any post box.
Return the kit
Your sample with be sequenced and your genes analysed. Results are usually reported within 4-5 weeks after receipt in the
laboratory. Urgent BRCA results are delivered in 2 weeks
Who can use the DNA test kit
Please be aware that these tests are only available to those aged 18 years or above.
How to read the genetic cancer screening results
All patients will have a pre-test telephone medical review before any sample is taken. Once we’ve completed testing your sample, one of our trained medical team will contact you to discuss your results.
Clear results about the presence or absence of any mutations that increase your risk for developing cancer will be conveyed.
A positive result
Confirms that a mutation or a genetic change in a specific gene has been identified. Your personal results will contain detailed risk information specific to the mutation identified in your genes, and our consultant will carefully talk you through this.
This result does not mean that you have cancer or that you will definitely develop cancer in your lifetime.
There may also be implications for other family members and our consultants will be able to discuss this with you when explaining your result.
A negative result
Means that no mutations or genetic changes were identified in the genes that were analysed.
This result does not eliminate your risk of developing cancer. You may still be at an increased risk due to other factors, such as mutations not detected by current technology, or mutations in other genes.
Prices cancer & cardiac genetic screening
- BRCA1/BRCA2 : £750.00
- Color 30 Gene Panel : £550.00
- 77 Cardiac Genes : £750.00
Combined screening including Color 30 Gene panel, BRCA 1/BRCA2 and cardiac profile:
- Extended 30 Gene panel: £815.00
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